The 312th prohibition is that we are forbidden from disagreeing with the Sages who pass down the Oral Tradition (may they rest in peace), or from deviating from any of their instructions in Torah matters.

The source of this prohibition is G‑d's statement1 (exalted be He), "Do not stray from the word that they declare to you."

The Sifri says, "The verse, 'Do not stray...' constitutes a prohibition."

One who violates this prohibition, i.e. a zaken mam're, is executed by strangulation if all the conditions described in the end of Sanhedrin2 are fulfilled. The details of this mitzvah are explained there.