Deuteronomy 17:16 "You shall never again return that way"
We are forbidden to return to Egypt in order to settle there.
After freeing us from slavery in Egypt, HaShem prohibited us from ever permanently living there again. However, it is permissible to return to Egypt for business or trade.



Re: as Anachronistic and meaningless.... For an extensive discussion on the prohibition of living in Egypt, as well as the glaring question of how could so many great sages such as Maimonides nevertheless live there, see The Prohibition Against Living in Egypt